Sensitive and selective methods for determination of antipsychotic drug olanzapine in pharmaceuticals

Title
Sensitive and selective methods for determination of antipsychotic drug olanzapine in pharmaceuticals
Author(s)
Dr. (Mrs) Anupama Asthana
Issue Date
01-10-2012
Citation
-
Document Abstract
Two simple and sensitive spectrophotometric methods have been developed for analysis of the antipsychotic drug olanzapine in pharmaceuticals. Method A is based on liberation of iodine by reaction between the drug and potassium iodate, followed by reaction with leuco crystal violet (LCV), the color of oxidized LCV being measured at 598 nm. Method B is based on oxidation of olanzapine with chloramine-T (CAT) in acidic medium, the unconsumed CAT being determined with rhodamine B, measuring the absorbance at 550 nm. Calibration graphs were linear over the ranges of 0.05–2.0 and 0.1–1.6 lg mL-1 olanzapine for method A and B, respectively. The molar absorptivity, Sandell’s sensitivity, detection limit, and quantitation limit were found to be 1.59 9 105, 0.00132, 0.038, and 0.117, respectively, for method A and 0.953 9 105, 0.00221, 0.064, and 0.192, respectively, for method B. The optimum conditions and other analytical parameters were evaluated. The proposed methods have been applied successfully for analysis of olanzapine in pure form and its dosage forms, and no interference was observed from common excipients present in pharmaceutical formulations.
Language
English
Document Year
2012
Subject Name
Chemistry
Publisher Name
Res Chem Interned
Rights :
All rights reserved at author