Document Abstract
A new simple and sensitive spectrophotometric method for some phenothiazine
derivatives has been developed.The proposedmethod is based on the reaction of
phenothiazine derivatives promethazine hydrochloride, chlorpromazine hydrochloride,
triflupromazine hydrochloride, prochlorperazine, and trifluoperazine with potassium
iodate followed by reaction of liberated iodine with leuco crystal violet (LCV) and
measurement of the color of the oxidized LCV at 598 nm. The method showed a good
linearity in the ranges 0.05–4.0, 0.02–2.0, 0.05–5.0, 0.1–8.0, and 0.05–2.0 lg mL-1
respectively. The optimum conditions and other analytical parameters were evaluated.
The proposed methods have been applied successfully to the analysis of phenothiazine
derivatives in pure form and in their dosage forms, and no interferencewas observed from
common excipients present in pharmaceutical formulations