Sensitive spectrophotometric method for determination of some phenothiazine drugs

Title
Sensitive spectrophotometric method for determination of some phenothiazine drugs
Author(s)
Dr. (Mrs) Anupama Asthana
Issue Date
15-05-2014
Citation
-
Document Abstract
A new simple and sensitive spectrophotometric method for some phenothiazine derivatives has been developed.The proposedmethod is based on the reaction of phenothiazine derivatives promethazine hydrochloride, chlorpromazine hydrochloride, triflupromazine hydrochloride, prochlorperazine, and trifluoperazine with potassium iodate followed by reaction of liberated iodine with leuco crystal violet (LCV) and measurement of the color of the oxidized LCV at 598 nm. The method showed a good linearity in the ranges 0.05–4.0, 0.02–2.0, 0.05–5.0, 0.1–8.0, and 0.05–2.0 lg mL-1 respectively. The optimum conditions and other analytical parameters were evaluated. The proposed methods have been applied successfully to the analysis of phenothiazine derivatives in pure form and in their dosage forms, and no interferencewas observed from common excipients present in pharmaceutical formulations
Language
English
Document Year
2014
Subject Name
Chemistry
Publisher Name
Res Chem Interned
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